A reversible haploid murine embryonic stem cell biobank resource for functional genomics

The ability to directly uncover the contributions of genes to a given phenotype is fundamental for biology research. However, ostensibly homogeneous cell populations exhibit large clonal variance1,2 that can confound analyses and undermine reproducibility3. Here, we used genome-saturated mutagenesis...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Elling, Ulrich, Wimmer, Reiner A., Leibbrandt, Andreas, Marquis, Julien, Burkard, Thomas, Michlits, Georg, Leopoldi, Alexandra, Micheler, Thomas, Abdeen, Dana, Zhuk, Sergei, Aspalter, Irene M., Levebvre, Gregory, Handl, Cornelia, Liebergesell, Julia, Hubmann, Maria, Husa, Anna-Maria, Kinzer, Manuela, Schuller, Nicole, Wetzel, Ellen, Van De Loo, Nina, Martinez, Jorge Arturo Zepeda, Estoppey, David, Riedl, Ralph, Yang, Fengtang, Fu, Beiyuan, Dechat, Thomas, Ivics, Zoltán, Agu, Chukwuma A., Bell, Oliver, Blaas, Dieter, Gerhardt, Holger, Hoepfner, Dominic, Descombes, Patrick, Stark, Alexander, Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235111/
https://ncbi.nlm.nih.gov/pubmed/28953874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24027
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