Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

[Image: see text] Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CENP-E) 3-chloro-N-{(1S)-2-[(N,N-d...

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Hauptverfasser: Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D., Parrish, Cynthia A., Duffy, Kevin J., Fitch, Duke M., Tedesco, Rosanna, Ashcraft, Luke W., Yao, Bing, Jiang, Hong, Huang, Jennifer K., Marin, Melchor V., Aroyan, Carrie E., Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L., Chaudhari, Amita M., Donatelli, Carla A., Darcy, Michael G., Ridgers, Lance H., Newlander, Ken A., Schmidt, Stanley J., Chai, Deping, Colón, Mariela, Zimmerman, Michael N., Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W., Finer, Jeffrey T., Wang, Zhengping, Morgan, Bradley P., Morgans, David J., Auger, Kurt R., Sung, Chiu-Mei, Carson, Jeff D., Luo, Lusong, Hugger, Erin D., Copeland, Robert A., Sutton, David, Elliott, John D., Jackson, Jeffrey R., Wood, Kenneth W., Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007900/
https://ncbi.nlm.nih.gov/pubmed/24900171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900018m
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