Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. We have identified GSK923295, an allosteric inhibitor of CENP-E kin...

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Bibliografiska uppgifter
Huvudupphovsmän: Wood, Kenneth W., Lad, Latesh, Luo, Lusong, Qian, Xiangping, Knight, Steven D., Nevins, Neysa, Brejc, Katjusa, Sutton, David, Gilmartin, Aidan G., Chua, Penelope R., Desai, Radhika, Schauer, Stephen P., McNulty, Dean E., Annan, Roland S., Belmont, Lisa D., Garcia, Carlos, Lee, Yan, Diamond, Melody A., Faucette, Leo F., Giardiniere, Michele, Zhang, ShuYun, Sun, Chiu-Mei, Vidal, Justin D., Lichtsteiner, Serge, Cornwell, William D., Greshock, Joel D., Wooster, Richard F., Finer, Jeffrey T., Copeland, Robert A., Huang, Pearl S., Morgans, David J., Dhanak, Dashyant, Bergnes, Gustave, Sakowicz, Roman, Jackson, Jeffrey R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851928/
https://ncbi.nlm.nih.gov/pubmed/20167803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915068107
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