Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. We have identified GSK923295, an allosteric inhibitor of CENP-E kin...

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Detalhes bibliográficos
Main Authors: Wood, Kenneth W., Lad, Latesh, Luo, Lusong, Qian, Xiangping, Knight, Steven D., Nevins, Neysa, Brejc, Katjusa, Sutton, David, Gilmartin, Aidan G., Chua, Penelope R., Desai, Radhika, Schauer, Stephen P., McNulty, Dean E., Annan, Roland S., Belmont, Lisa D., Garcia, Carlos, Lee, Yan, Diamond, Melody A., Faucette, Leo F., Giardiniere, Michele, Zhang, ShuYun, Sun, Chiu-Mei, Vidal, Justin D., Lichtsteiner, Serge, Cornwell, William D., Greshock, Joel D., Wooster, Richard F., Finer, Jeffrey T., Copeland, Robert A., Huang, Pearl S., Morgans, David J., Dhanak, Dashyant, Bergnes, Gustave, Sakowicz, Roman, Jackson, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851928/
https://ncbi.nlm.nih.gov/pubmed/20167803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915068107
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