Age Enhanced ER Stress Contributes to Increased Atg9A Inhibition of STING Mediated IFNβ Production during Streptococcus Pneumoniae Infection

Pneumococcal infections remain a leading cause of death in persons ≥ 65 years of age. Recent reports have illustrated detrimental changes in the ER stress response or unfolded protein response (UPR) in aging and age-related diseases; however the relationship between aging, the UPR, and innate immune...

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Bibliographic Details
Main Authors: Mitzel, Dana N., Lowry, Virginia, Shirali, Anushree C., Liu, Yushi, Stout-Delgado, Heather W.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007355/
https://ncbi.nlm.nih.gov/pubmed/24670807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303090
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