TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN

Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce type-1 immune responses. However, currently available CpG oligodeoxynucleotide (ODN) (K-type) induces IFNs only weakly and STING ligands rather induce type-2 immune responses, limiting their potential therapeut...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Temizoz, Burcu, Kuroda, Etsushi, Ohata, Keiichi, Jounai, Nao, Ozasa, Koji, Kobiyama, Kouji, Aoshi, Taiki, Ishii, Ken J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Innate Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671267/
https://ncbi.nlm.nih.gov/pubmed/25529558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445132
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