Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α(1)-antitrypsin

Overexpression of Z α(1)-antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary bronchial epithelial cells has similar consequences remains unclear. M...

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Main Authors: van ‘t Wout, Emily F.A., Dickens, Jennifer A., van Schadewijk, Annemarie, Haq, Imran, Kwok, Hang Fai, Ordóñez, Adriana, Murphy, Gillian, Stolk, Jan, Lomas, David A., Hiemstra, Pieter S., Marciniak, Stefan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007119/
https://ncbi.nlm.nih.gov/pubmed/24097797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt487
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