Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals

AIM: To investigate the pharmacokinetics and disposition of simmitecan (L-P) that was a water-soluble ester prodrug of chimmitecan (L-2-Z) with potent anti-tumor activities in different experimental animals, and to assess its drug-drug interaction potential. METHODS: SD rats were injected with a sin...

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Main Authors: Hu, Zhe-yi, Li, Xiu-xue, Du, Fei-fei, Yang, Jun-ling, Niu, Wei, Xu, Fang, Wang, Feng-qing, Li, Chuan, Sun, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006472/
https://ncbi.nlm.nih.gov/pubmed/24056706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.74
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