Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380

Through synthetic lethality screening of isogenic cell lines with and without the oncogenic KRAS gene and through lead compound optimization, we recently developed a novel anticancer agent designated NSC-743380 (oncrasin-72) that has promising in vitro and in vivo anticancer activity in a subset of...

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Detalhes bibliográficos
Main Authors: Wu, Shuhong, Wang, Li, Huang, Xiao, Cao, Mengru, Hu, Jing, Li, Hongyu, Zhang, Hui, Sun, Xiaoping, Meng, Qing H., Hofstetter, Wayne L., Roth, Jack A., Swisher, Stephen G., Fang, Bingliang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172508/
https://ncbi.nlm.nih.gov/pubmed/25182964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.08.006
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