Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2-Null Mice

The chemotherapeutic drug cisplatin is actively transported into proximal tubules, leading to acute renal injury. Previous studies suggest that the multidrug resistance–associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from cells. We sought to determine whether the absence of M...

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Detalhes bibliográficos
Main Authors: Wen, Xia, Buckley, Brian, McCandlish, Elizabeth, Goedken, Michael J., Syed, Samira, Pelis, Ryan, Manautou, José E., Aleksunes, Lauren M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005989/
https://ncbi.nlm.nih.gov/pubmed/24641901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.01.025
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