Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

Treatment with hepatotoxicants such as acetaminophen (APAP) causes resistance to a second, higher dose of the same toxicant (autoprotection). APAP induces hepatic mRNA and protein levels of the multidrug resistance-associated proteins (Mrp) transporters in mice and humans. Basolateral efflux transpo...

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Hlavní autoři: Aleksunes, Lauren M., Campion, Sarah N., Goedken, Michael J., Manautou, José E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Biotransformation and Toxicokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734298/
https://ncbi.nlm.nih.gov/pubmed/18468992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn093
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