Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

During acetaminophen (APAP) hepatotoxicity, increased expression of multidrug resistance-associated proteins 2, 3, and 4 (Mrp2-4) occurs. Mrp4 is the most significantly upregulated transporter in mouse liver following APAP treatment. Although the expression profiles of liver transporters following A...

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Autores principales: Campion, Sarah N., Johnson, Rachel, Aleksunes, Lauren M., Goedken, Michael J., van Rooijen, Nico, Scheffer, George L., Cherrington, Nathan J., Manautou, José E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2008
Materias:
Liver and Biliary Tract
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519859/
https://ncbi.nlm.nih.gov/pubmed/18556419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00541.2007
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