Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

The use of the chemotherapeutic drug cisplatin is limited in part by nephrotoxicity. Cisplatin causes renal DNA adducts and oxidative stress in rodents. The transcription factor Nrf2 (nuclear factor E2-related factor 2) induces expression of cytoprotective genes, including Nqo1 (NADPH:quinone oxidor...

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Bibliographic Details
Main Authors: Aleksunes, Lauren M., Goedken, Michael J., Rockwell, Cheryl E., Thomale, Juergen, Manautou, Jose E., Klaassen, Curtis D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
Subjects:
Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957774/
https://ncbi.nlm.nih.gov/pubmed/20605904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.170084
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