Coordinated Induction of Nrf2 Target Genes Protects Against Iron Nitrilotriacetate (FeNTA)-Induced Nephrotoxicity

The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage. Chronic exposure of FeNTA leads to a high incidence of renal adenocarcinomas in rodents. NF-e2-related factor 2 (Nrf2) is a transcription fa...

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Main Authors: Tanaka, Yuji, Aleksunes, Lauren M., Goedken, Michael J., Chen, Chuan, Reisman, Scott A., Manautou, José E., Klaassen, Curtis D.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582522/
https://ncbi.nlm.nih.gov/pubmed/18617210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2008.05.022
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