Protein Tyrosine Phosphatase α Mediates Profibrotic Signaling in Lung Fibroblasts through TGF-β Responsiveness

Fibrotic lung diseases represent a diverse group of progressive and often fatal disorders with limited treatment options. Although the pathogenesis of these conditions remains incompletely understood, receptor type protein tyrosine phosphatase α (PTP-α encoded by PTPRA) has emerged as a key regulato...

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Hlavní autoři: Aschner, Yael, Khalifah, Anthony P., Briones, Natalie, Yamashita, Cory, Dolgonos, Lior, Young, Scott K., Campbell, Megan N., Riches, David W.H., Redente, Elizabeth F., Janssen, William J., Henson, Peter M., Sap, Jan, Vacaresse, Nathalie, Kapus, Andras, McCulloch, Christopher A.G., Zemans, Rachel L., Downey, Gregory P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2014
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005983/
https://ncbi.nlm.nih.gov/pubmed/24650563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.01.016
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