Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages

Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which alternatively programmed macrophages produce profibrotic molecules that promote myofibroblast survival and collagen synthesis. Effective therapies to treat patients with IPF are lacking, and conventional...

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Detalhes bibliográficos
Main Authors: Redente, Elizabeth F., Keith, Rebecca C., Janssen, William, Henson, Peter M., Ortiz, Luis A., Downey, Gregory P., Bratton, Donna L., Riches, David W. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068926/
https://ncbi.nlm.nih.gov/pubmed/24325577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0386OC
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