Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

The reverse transcriptase inhibitor 9-[2-(phosphonomethoxy)propyl]adenine (PMPA; tenofovir) was previously found to offer strong prophylactic and therapeutic benefits in an infant macaque model of pediatric human immunodeficiency virus (HIV) infection. We now summarize the toxicity and safety of PMP...

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Autors principals: Van Rompay, Koen K. A., Brignolo, Laurie L., Meyer, Dennis J., Jerome, Christopher, Tarara, Ross, Spinner, Abigail, Hamilton, Marta, Hirst, Linda L., Bennett, David R., Canfield, Don R., Dearman, Trish G., Von Morgenland, Wilhelm, Allen, Phil C., Valverde, Celia, Castillo, Alesha B., Martin, R. Bruce, Samii, Valerie F., Bendele, Ray, Desjardins, John, Marthas, Marta L., Pedersen, Niels C., Bischofberger, Norbert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC400569/
https://ncbi.nlm.nih.gov/pubmed/15105094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1469-1487.2004
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