Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) is the rate-limiting step in cholesterol biosynthesis and cataly...

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Главные авторы: Yeganeh, Behzad, Wiechec, Emmilia, Ande, Sudharsana R, Sharma, Pawan, Moghadam, Adel Rezaei, Post, Martin, Freed, Darren H., Hashemi, Mohammad, Shojaei, Shahla, Zeki, Amir A., Ghavami, Saeid
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005604/
https://ncbi.nlm.nih.gov/pubmed/24582968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.02.007
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