Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significa...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Alizadeh, Javad, Zeki, Amir A., Mirzaei, Nima, Tewary, Sandipan, Rezaei Moghadam, Adel, Glogowska, Aleksandra, Nagakannan, Pandian, Eftekharpour, Eftekhar, Wiechec, Emilia, Gordon, Joseph W., Xu, Fred. Y., Field, Jared T., Yoneda, Ken Y., Kenyon, Nicholas J., Hashemi, Mohammad, Hatch, Grant M., Hombach-Klonisch, Sabine, Klonisch, Thomas, Ghavami, Saeid
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366866/
https://ncbi.nlm.nih.gov/pubmed/28344327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44841
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