Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significa...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Alizadeh, Javad, Zeki, Amir A., Mirzaei, Nima, Tewary, Sandipan, Rezaei Moghadam, Adel, Glogowska, Aleksandra, Nagakannan, Pandian, Eftekharpour, Eftekhar, Wiechec, Emilia, Gordon, Joseph W., Xu, Fred. Y., Field, Jared T., Yoneda, Ken Y., Kenyon, Nicholas J., Hashemi, Mohammad, Hatch, Grant M., Hombach-Klonisch, Sabine, Klonisch, Thomas, Ghavami, Saeid
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366866/
https://ncbi.nlm.nih.gov/pubmed/28344327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44841
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk