Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond

Rationale: Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. Objectives: To determine whether simvastatin att...

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Detalles Bibliográficos
Main Authors: Zeki, Amir A., Franzi, Lisa, Last, Jerold, Kenyon, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2009
Assuntos:
B. Asthma and Allergy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778150/
https://ncbi.nlm.nih.gov/pubmed/19608720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200901-0018OC
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