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Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond

Rationale: Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. Objectives: To determine whether simvastatin att...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zeki, Amir A., Franzi, Lisa, Last, Jerold, Kenyon, Nicholas J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778150/
https://ncbi.nlm.nih.gov/pubmed/19608720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200901-0018OC
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