Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) is the rate-limiting step in cholesterol biosynthesis and cataly...

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Détails bibliographiques
Auteurs principaux: Yeganeh, Behzad, Wiechec, Emmilia, Ande, Sudharsana R, Sharma, Pawan, Moghadam, Adel Rezaei, Post, Martin, Freed, Darren H., Hashemi, Mohammad, Shojaei, Shahla, Zeki, Amir A., Ghavami, Saeid
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005604/
https://ncbi.nlm.nih.gov/pubmed/24582968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.02.007
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