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Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) is the rate-limiting step in cholesterol biosynthesis and cataly...

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Bibliografische gegevens
Hoofdauteurs: Yeganeh, Behzad, Wiechec, Emmilia, Ande, Sudharsana R, Sharma, Pawan, Moghadam, Adel Rezaei, Post, Martin, Freed, Darren H., Hashemi, Mohammad, Shojaei, Shahla, Zeki, Amir A., Ghavami, Saeid
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005604/
https://ncbi.nlm.nih.gov/pubmed/24582968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.02.007
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