Biochemical Characterization of Streptococcus pneumoniae Penicillin-Binding Protein 2b and Its Implication in β-Lactam Resistance

Extensive use of β-lactam antibiotics has led to the selection of pathogenic streptococci resistant to β-lactams due to modifications of the penicillin-binding proteins (PBPs). PBP2b from Streptococcus pneumoniae is a monofunctional (class B) high-molecular-weight PBP catalyzing the transpeptidation...

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Bibliographic Details
Main Authors: Pagliero, Estelle, Chesnel, Laurent, Hopkins, Julie, Croizé, Jacques, Dideberg, Otto, Vernet, Thierry, Di Guilmi, Anne Marie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC400559/
https://ncbi.nlm.nih.gov/pubmed/15105143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1848-1855.2004
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