CD4-Induced T-20 Binding to Human Immunodeficiency Virus Type 1 gp120 Blocks Interaction with the CXCR4 Coreceptor

The synthetic peptide T-20, which corresponds to a sequence within the C-terminal heptad repeat region (HR2) of the human immunodeficiency virus type 1 (HIV-1) gp41 envelope glycoprotein, potently inhibits viral membrane fusion and entry. Although T-20 is thought to bind the N-terminal heptad repeat...

Full description

Saved in:
Bibliographic Details
Main Authors: Yuan, Wen, Craig, Stewart, Si, Zhihai, Farzan, Michael, Sodroski, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC400340/
https://ncbi.nlm.nih.gov/pubmed/15113923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.10.5448-5457.2004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items