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Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels

AIM: Retigabine, an activator of KCNQ2-5 channels, is currently used to treat partial-onset seizures. The aim of this study was to explore the possibility that structure modification of retigabine could lead to novel inhibitors of KCNQ2 channels, which were valuable tools for KCNQ channel studies. M...

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Autori principali: Hu, Hai-ning, Zhou, Ping-zheng, Chen, Fei, Li, Min, Nan, Fa-jun, Gao, Zhao-bing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002159/
https://ncbi.nlm.nih.gov/pubmed/23933653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.79
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