Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels

AIM: Retigabine, an activator of KCNQ2-5 channels, is currently used to treat partial-onset seizures. The aim of this study was to explore the possibility that structure modification of retigabine could lead to novel inhibitors of KCNQ2 channels, which were valuable tools for KCNQ channel studies. M...

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מידע ביבליוגרפי
Main Authors: Hu, Hai-ning, Zhou, Ping-zheng, Chen, Fei, Li, Min, Nan, Fa-jun, Gao, Zhao-bing
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2013
נושאים:
Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002159/
https://ncbi.nlm.nih.gov/pubmed/23933653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.79
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