Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia

Vascular dysfunction has been associated with familial hypercholesterolaemia (FH), a severe form of hyperlipidaemia. We recently demonstrated that swine with FH exhibit reduced exercise-induced systemic, but not pulmonary, vasodilatation involving reduced nitric oxide (NO) bioavailability. Since NO...

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Autores principales: Bender, Shawn B, de Beer, Vincent J, Tharp, Darla L, van Deel, Elza D, Bowles, Douglas K, Duncker, Dirk J, Laughlin, M Harold, Merkus, Daphne
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001750/
https://ncbi.nlm.nih.gov/pubmed/24421352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.267351
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