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Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: effects of PDE5 inhibition

OBJECTIVE: Swine with familial hypercholesterolemia (FH) exhibit attenuated exercise-induced systemic vasodilation that is restored by phosphodiesterase 5 (PDE5) inhibition. Whether the impacts of FH and PDE5 inhibition to impair and restore, respectively, exercise-induced vasodilation results from...

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Опубликовано в: :Microcirculation
Главные авторы: Aragonez, Christian G., de Beer, Vincent J., Tharp, Darla L., Bowles, Douglas K., Laughlin, M. Harold, Merkus, Daphne, Duncker, Dirk J., Bender, Shawn B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711790/
https://ncbi.nlm.nih.gov/pubmed/30821858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/micc.12539
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