Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability

Hypercholesterolemia impairs endothelial function [e.g., the nitric oxide (NO)-cyclic GMP-phosphodiesterase 5 (PDE5) pathway], limits shear stress-induced vasodilation, and is therefore expected to reduce exercise-induced vasodilation. To assess the actual effects of hypercholesterolemia on endothel...

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Detalhes bibliográficos
Main Authors: de Beer, Vincent J., Merkus, Daphne, Bender, Shawn B., Tharp, Darla L., Bowles, Douglas K., Duncker, Dirk J., Laughlin, M. Harold
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882941/
https://ncbi.nlm.nih.gov/pubmed/24157527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00619.2013
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