Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is mediated in part via an increase in endothelin production

Nitric oxide (NO)-induced coronary vasodilation is mediated through production of cyclic guanosine monophosphate (cGMP) and through inhibition of the endothelin-1 (ET) system. We previously demonstrated that phosphodiesterase-5 (PDE5)-mediated cGMP breakdown and ET each exert a vasoconstrictor influ...

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Detalhes bibliográficos
Main Authors: Zhou, Zhichao, de Beer, Vincent J., Bender, Shawn B., Jan Danser, A. H., Merkus, Daphne, Laughlin, M. Harold, Duncker, Dirk J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949052/
https://ncbi.nlm.nih.gov/pubmed/24464751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00331.2013
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