Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic instability, apoptosis, or senescence. Incorrectly repaired DNA DSBs have the...

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Detalhes bibliográficos
Main Authors: Jekimovs, Christian, Bolderson, Emma, Suraweera, Amila, Adams, Mark, O’Byrne, Kenneth J., Richard, Derek J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001069/
https://ncbi.nlm.nih.gov/pubmed/24795863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00086
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