Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad and the promising

The repair of DNA double-strand breaks is a critical cellular mechanism that exists to ensure genomic stability. DNA double-strand breaks are the most deleterious type of insult to a cells genetic material and can lead to genomic instability, apoptosis or senescence. Incorrectly repaired DNA double-...

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Detaylı Bibliyografya
Asıl Yazarlar: Christian Robert Jekimovs, Emma eBolderson, Amila eSuraweera, Mark eAdams, Kenneth John O'Byrne, Derek John Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2014-04-01
Seri Bilgileri:Frontiers in Oncology
Konular:
Cancer
DNA damage repair
DNA damage response
chemotherapeutic compounds
radiosensitise
radioprotective
Online Erişim:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00086/full
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