COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

Genomic stability is critical for normal cellular function and its deregulation is a universal hallmark of cancer. Here we outline a previously undescribed role of COMMD4 in maintaining genomic stability, by regulation of chromatin remodelling at sites of DNA double-strand breaks. At break-sites, CO...

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Vydáno v:Commun Biol
Hlavní autoři: Suraweera, Amila, Gandhi, Neha S., Beard, Sam, Burgess, Joshua T., Croft, Laura V., Bolderson, Emma, Naqi, Ali, Ashton, Nicholas W., Adams, Mark N., Savage, Kienan I., Zhang, Shu-Dong, O’Byrne, Kenneth J., Richard, Derek J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055684/
https://ncbi.nlm.nih.gov/pubmed/33875784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01998-2
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