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SDS, a structural disruption score for assessment of missense variant deleteriousness

We have developed a novel structure-based evaluation for missense variants that explicitly models protein structure and amino acid properties to predict the likelihood that a variant disrupts protein function. A structural disruption score (SDS) is introduced as a measure to depict the likelihood th...

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Bibliografski detalji
Glavni autori: Preeprem, Thanawadee, Gibson, Greg
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001065/
https://ncbi.nlm.nih.gov/pubmed/24795746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00082
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