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SDS, a structural disruption score for assessment of missense variant deleteriousness
We have developed a novel structure-based evaluation for missense variants that explicitly models protein structure and amino acid properties to predict the likelihood that a variant disrupts protein function. A structural disruption score (SDS) is introduced as a measure to depict the likelihood th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001065/ https://ncbi.nlm.nih.gov/pubmed/24795746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00082 |
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