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Structural dynamics is a determinant of the functional significance of missense variants

Accurate evaluation of the effect of point mutations on protein function is essential to assessing the genesis and prognosis of many inherited diseases and cancer types. Currently, a wealth of computational tools has been developed for pathogenicity prediction. Two major types of data are used to th...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ponzoni, Luca, Bahar, Ivet
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910821/
https://ncbi.nlm.nih.gov/pubmed/29610305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715896115
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