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Structural dynamics is a determinant of the functional significance of missense variants

Accurate evaluation of the effect of point mutations on protein function is essential to assessing the genesis and prognosis of many inherited diseases and cancer types. Currently, a wealth of computational tools has been developed for pathogenicity prediction. Two major types of data are used to th...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ponzoni, Luca, Bahar, Ivet
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910821/
https://ncbi.nlm.nih.gov/pubmed/29610305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715896115
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