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Structural dynamics is a determinant of the functional significance of missense variants
Accurate evaluation of the effect of point mutations on protein function is essential to assessing the genesis and prognosis of many inherited diseases and cancer types. Currently, a wealth of computational tools has been developed for pathogenicity prediction. Two major types of data are used to th...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5910821/ https://ncbi.nlm.nih.gov/pubmed/29610305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715896115 |
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