Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

The functional role of pericytes in cancer progression remains unknown. Clinical studies suggest that low numbers of vessel-associated pericytes correlated with a drop in overall survival of patients with invasive breast cancer. Using genetic mouse models or pharmacological inhibitors, pericyte depl...

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Hauptverfasser: Cooke, Vesselina G., LeBleu, Valerie S., Keskin, Doruk, Khan, Zainab, O’Connell, Joyce T., Teng, Yingqi, Duncan, Michael B., Xie, Liang, Maeda, Genta, Vong, Sylvia, Sugimoto, Hikaru, Rocha, Rafael M., Damascena, Aline, Brentani, Ricardo R., Kalluri, Raghu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999522/
https://ncbi.nlm.nih.gov/pubmed/22264789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.11.024
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