Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. Rods form rapidly (5–30 min) in >...

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Main Authors: Walsh, Keifer P., Minamide, Laurie S., Kane, Sarah J., Shaw, Alisa E., Brown, David R., Pulford, Bruce, Zabel, Mark D., Lambeth, J. David, Kuhn, Thomas B., Bamburg, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997518/
https://ncbi.nlm.nih.gov/pubmed/24760020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095995
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