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Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation

Actin and its key regulatory component cofilin are found together in large rod-shaped assemblies in neurons subjected to energy stress. Such inclusions are also enriched in Alzheimer’s disease brain, and appear in transgenic models of neurodegeneration. Neuronal insults such as energy loss and/or ox...

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Hlavní autoři: Huang, Timothy Y., Minamide, Laurie S., Bamburg, James R., Bokoch, Gary M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644054/
https://ncbi.nlm.nih.gov/pubmed/19000834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.09.017
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