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Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation
Actin and its key regulatory component cofilin are found together in large rod-shaped assemblies in neurons subjected to energy stress. Such inclusions are also enriched in Alzheimer’s disease brain, and appear in transgenic models of neurodegeneration. Neuronal insults such as energy loss and/or ox...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644054/ https://ncbi.nlm.nih.gov/pubmed/19000834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.09.017 |
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