Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. Rods form rapidly (5–30 min) in >...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Walsh, Keifer P., Minamide, Laurie S., Kane, Sarah J., Shaw, Alisa E., Brown, David R., Pulford, Bruce, Zabel, Mark D., Lambeth, J. David, Kuhn, Thomas B., Bamburg, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997518/
https://ncbi.nlm.nih.gov/pubmed/24760020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095995
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi