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Stilbenes as κ-Selective, Non-nitrogenous Opioid Receptor Antagonists

[Image: see text] The natural stilbene pawhuskin A has been shown to function as an opioid receptor antagonist, with preferential binding to the κ receptor. This finding encouraged assembly of a set of analogues to probe the importance of key structural features. Assays on these compounds determined...

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Autors principals: Hartung, Alyssa M., Beutler, John A., Navarro, Hernán A., Wiemer, David F., Neighbors, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society and American Society of Pharmacognosy 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993902/
https://ncbi.nlm.nih.gov/pubmed/24456556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np4009046
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