Lymphocyte Gene Expression and JC Virus Noncoding Control Region Sequences Are Linked with the Risk of Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML)-derived noncoding control region (NCCR) sequences permitted greater early viral gene expression than kidney-associated NCCR sequences. This was driven in part by binding of the transcription factor Spi-B to unique PML-associated Spi-B binding sites. S...

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Detalhes bibliográficos
Main Authors: Marshall, Leslie J., Ferenczy, Michael W., Daley, Elizabeth L., Jensen, Peter N., Ryschkewitsch, Caroline F., Major, Eugene O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993791/
https://ncbi.nlm.nih.gov/pubmed/24554653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03221-13
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