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Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication Rate

Polyomavirus JC (JCV) infects ∼60% of the general population, followed by asymptomatic urinary shedding in ∼20%. In patients with pronounced immunodeficiency, including HIV/AIDS, JCV can cause progressive multifocal leukoencephalopathy (PML), a devastating brain disease of high mortality. While JCV...

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Main Authors: Gosert, Rainer, Kardas, Piotr, Major, Eugene O., Hirsch, Hans H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950575/
https://ncbi.nlm.nih.gov/pubmed/20686041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00614-10
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