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A histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant
Mutations of the thyroid hormone receptor α gene (THRA) cause hypothyroidism in patients with growth and developmental retardation, and skeletal dysplasia. Genetic evidence indicates that the dominant negative activity of TRα1 mutants underlies pathological manifestations. Using a mouse model of hyp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990165/ https://ncbi.nlm.nih.gov/pubmed/24381310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt660 |
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