Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene

Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1(PV/+) mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using Thra...

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Udgivet i:PLoS Genet
Main Authors: Park, Sunmi, Han, Cho Rong, Park, Jeong Won, Zhao, Li, Zhu, Xuguang, Willingham, Mark, Bodine, David M., Cheng, Sheue-yann
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621702/
https://ncbi.nlm.nih.gov/pubmed/28910278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006991
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