Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene.
Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1PV/+ mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using Thra1P...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science (PLoS)
2017-09-01
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| Seri Bilgileri: | PLoS Genetics |
| Online Erişim: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006991&type=printable |
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