Defining the Conformation of the Estrogen Receptor Complex That Controls Estrogen-Induced Apoptosis in Breast Cancer

Development of acquired antihormone resistance exposes a vulnerability in breast cancer: estrogen-induced apoptosis. Triphenylethylenes (TPEs), which are structurally similar to 4-hydroxytamoxifen (4OHT), were used for mechanistic studies of estrogen-induced apoptosis. These TPEs all stimulate growt...

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Bibliographic Details
Main Authors: Obiorah, Ifeyinwa, Sengupta, Surojeet, Curpan, Ramona, Jordan, V. Craig
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990021/
https://ncbi.nlm.nih.gov/pubmed/24608856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089250
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