Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer

Estrogen therapy was used to treat advanced breast cancer in postmenopausal women for decades until the introduction of tamoxifen. Resistance to long-term estrogen deprivation (LTED) with tamoxifen and aromatase inhibitors used as a treatment of breast cancer inevitably occurs, but unexpectedly low-...

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Publicado no:Mol Pharmacol
Main Authors: Maximov, Philipp Y., Abderrahman, Balkees, Fanning, Sean W., Sengupta, Surojeet, Fan, Ping, Curpan, Ramona F., Rincon, Daniela Maria Quintana, Greenland, Jeffery A., Rajan, Shyamala S., Greene, Geoffrey L., Jordan, V. Craig
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022805/
https://ncbi.nlm.nih.gov/pubmed/29739819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.111385
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