Estrogen Receptor Mutations Found in Breast Cancer Metastases Integrated With the Molecular Pharmacology of Selective ER Modulators

The consistent reports of mutations at Asp538 and Tyr537 in helix 12 of the ligand-binding domain (LBD) of estrogen receptors (ERs) from antihormone-resistant breast cancer metastases constitute an important advance. The mutant amino acids interact with an anchor amino acid, Asp351, to close the LBD...

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Bibliografiska uppgifter
I publikationen:J Natl Cancer Inst
Huvudupphovsmän: Jordan, V. Craig, Curpan, Ramona, Maximov, Philipp Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Commentary
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390275/
https://ncbi.nlm.nih.gov/pubmed/25838462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv075
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