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Estrogen Receptor Mutations Found in Breast Cancer Metastases Integrated With the Molecular Pharmacology of Selective ER Modulators

The consistent reports of mutations at Asp538 and Tyr537 in helix 12 of the ligand-binding domain (LBD) of estrogen receptors (ERs) from antihormone-resistant breast cancer metastases constitute an important advance. The mutant amino acids interact with an anchor amino acid, Asp351, to close the LBD...

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Bibliografiske detaljer
Udgivet i:J Natl Cancer Inst
Main Authors: Jordan, V. Craig, Curpan, Ramona, Maximov, Philipp Y.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390275/
https://ncbi.nlm.nih.gov/pubmed/25838462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv075
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