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Estrogen Receptor Mutations Found in Breast Cancer Metastases Integrated With the Molecular Pharmacology of Selective ER Modulators

The consistent reports of mutations at Asp538 and Tyr537 in helix 12 of the ligand-binding domain (LBD) of estrogen receptors (ERs) from antihormone-resistant breast cancer metastases constitute an important advance. The mutant amino acids interact with an anchor amino acid, Asp351, to close the LBD...

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Detaylı Bibliyografya
Yayımlandı:J Natl Cancer Inst
Asıl Yazarlar: Jordan, V. Craig, Curpan, Ramona, Maximov, Philipp Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390275/
https://ncbi.nlm.nih.gov/pubmed/25838462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv075
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