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Context-Dependent Antagonism between Akt Inhibitors and Topoisomerase Poisons
Signaling through the phosphatidylinositol-3 kinase (PI3K)/Akt pathway, which is aberrantly activated in >50% of carcinomas, inhibits apoptosis and contributes to drug resistance. Accordingly, several Akt inhibitors are currently undergoing preclinical or early clinical testing. To examine the ef...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990016/ https://ncbi.nlm.nih.gov/pubmed/24569089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088674 |
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